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33 SugaharaMTanakaSTanakaTSaitoHIshimotoYWakashimaTet al

10 The first step in the biosynthesis of GSH is rate-limiting and is catalysed by glutamate-cysteine ligase (GCL)

For example, Parkinsons and Alzheimers diseases have high levels of oxidative stress and damage to the brain with correspondingly low active glutathione (GSH) levels