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Endogenous MOTS-c levels rise during exercise in human plasma (D'Souza et al., 2020, PMID 32182209)
The three-carbon sugar generated is glyceraldehyde-3-phosphate which can be shunted to glycolysis and oxidized to pyruvate
Notably, studies on another GLP-1 drug, semaglutide (Wegovy, Ozempic), have found that gastrointestinal side effects such as nausea, diarrhea, and vomiting are relatively shortlived, lasting 2 to 8 days
These medications are generally well tolerated, and most symptoms can be worked through safely with the right guidance
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![Tirzepatide vs. Semaglutide: Which GLP-1 Better Preserves Muscle? [SURMOUNT-5 Data]](https://www.clinicalnutritioncenter.com/wp-content/uploads/2026/04/research-image-2026-04-10.jpg)
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