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New England Journal of Medicine , 2015;373(1):11-22
Phase 1 studies in healthy volunteers demonstrated acceptable safety and tolerability
In addition to summarising the current progress, this review also emphasises the emerging integration of medicinal chemistry and delivery science as the basis for the development of intelligent, safe and clinically convertible PROTAC therapies, so as to promote the evolution of precise protein degradation to a mature drug discovery paradigm
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