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Early Phase 2 data suggest substantial weight loss, though it is important to note that no direct head-to-head trials comparing retatrutide with tirzepatide or other agents have been conducted

If you have a history of anxiety disorders , depression, or other mental health conditions, the SURMOUNT data does not directly apply to your situation

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Existing GLP1R agonists come with boxed warnings of thyroid cancer and pancreatitis, based mainly on rodent studies, where the effects of GLP1R agonism have noted species differences (For example, weight loss in rodents is mainly due to increased energy expenditure, whereas in humans it occurs via less food intake [54] )

I = 21.2%, p = 0.267)