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Clinical trials have shown that patients taking Zepbound achieved greater average weight loss than those on semaglutide-based therapies, with high-dose participants losing up to 21% of body weightover 18 months

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Storage requirements vary between injectable and oral forms of semaglutide

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It was also an early observation that a higher dose of GLP-1 is needed to produce satiety and reduced food intake than to the antidiabetic effect, so a low dose GLP-1 analog could be used to study weight loss independent effects of GLP-1