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Given the effects of HBOT on Nrf2 upregulation (2729) and of NRF2 effects on intracellular glutathione (GSH) (30), supplemental GSH precursors were recommended adjunctively during hyperbaric treatment

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Concurrent activation of the ascorbateglutathione (AsA-GSH) cycle maintained redox equilibrium during early stress phases, though prolonged exposure imposed redox constraints

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