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Dehydration adds to the tired feeling and often gets missed because thirst cues drop alongside hunger cues

The Proteomics Protocols Handbook 20 GuanC.WangX.FengJ.HongS.LiangY.RenB.et al (2014)

Glucagon-like peptide-1 (GLP-1) receptor agonists, also known as GLP-1 agonists, GLP-IRAs, GLP-1 analogs, or incretin mimetics, are a class of medications that activate the GLP-1 receptor, leading to reduced blood sugar levels and decreased appetite, which in turn results in lower energy intake

GLP-1 medications may reduce these thoughts for some patients, but they can return after treatment ends

However, while the technology shows promise, current clinical data remains limited