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4A) and the number of crossings (horizontal activity) (Fig

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[DOI] [PubMed] [PMC] Roth RA, Ganey PE

Pernicious anemia occurs more commonly in people who already have diseases that are linked to immune-system abnormalities, such as Graves disease, hypothyroidism (under-functioning thyroid gland), thyroiditis (inflammation of the thyroid), vitiligo, and Addison's disease (adrenocortical insufficiency)

However, the skin begins to respond to the inhibition of melanin production