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However, critical barriers hinder their clinical translation: (1) regulatory and scalability challenges, such as standardizing sterilization/long-term stability for liposomes/SLNs, require rigorous evaluation of immune responses (e.g., PEGylated liposomal uricase) and cost-effectiveness for advanced systems (biomimetic nanoliposomes and ethosomal gels)

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The GIP receptor-mediated effects on adipose tissue metabolism appear to target visceral fat preferentially, making tirzepatide particularly effective for this metabolically high-risk phenotype