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DSIP is a synthetic nonapeptide (Trp Ala Gly Gly Asp Ala Ser Gly Glu) modeled after a naturally occurring neuropeptide involved in sleep and neuroendocrine regulation

The injection of MS275 (a specific class I HDACi) into NAc was found to have a powerful antidepressant effect, suggesting that histone acetylation plays an adaptive role in the stress response 140

PMID 17464988

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