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Its main principles include that it can inhibit the feeding center, thus reducing appetite
Any haziness indicates peptide aggregation or contamination
& Ye, B
That flat selectivity profile is precisely what keeps MT2 useful in vitro: it serves as the positive-control full agonist against which subtype-selective ligands are benchmarked, and it is the parent scaffold for a large derivative family generated by single substitutions at positions 6, 7 and 9, including the MC3R/MC4R antagonist SHU-9119
Hinds M, et al
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