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In rodent studies, exendin-4 and dulaglutide have been detected in the brain following systemic administration, supporting their ability to engage central GLP-1 receptors, and these compounds are generally considered to be capable of penetrating the BBB ( via neuroinflammatory and oxidative stress pathways ( Furthermore, nausea is among the most common side effects associated with GLP-1 receptor agonists in humans ( A limitation of the present study is the use of male rats, as sex-dependent differences have been reported across different stages of METH addiction in both humans and rodents ( In conclusion, this study demonstrates that repeated administration of the GLP-1 receptor agonist liraglutide significantly reduces METH intake during the maintenance phase of operant intravenous self-administration in a short-access model