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While it has gained widespread off-label use for weight loss, and a higher-dose version, Wegovy, is approved for obesity management, the claims of penile enlargement add to a growing list of alleged side effects, including "Ozempic mouth," which involves pronounced folds and sagging around the mouth area
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The bioavailability in the portal vein is important, since there are GLP-1 receptors in both the portal vein, and on the membranes of vagal afferent nerve cell in the intestine, which will be accessed by the peptide before it reaches the outer circulation
Patients should avoid excessive fluid intake beyond physiological needs, as this can increase urinary frequency unnecessarily
