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[11] TMG can help replenish methyl groups and facilitate the clearance of nicotinamide, theoretically reducing the buildup of by-products that could cause fatigue or headaches in some individuals

But it can also lead to loss of lean muscle if not managed carefully

Individuals with certain gastrointestinal conditions affecting absorptionincluding inflammatory bowel disease, coeliac disease, or those who have undergone bariatric surgerymay need B12 supplementation

Pregnant or breastfeeding women should consult their physician before use

for neutral grounding on indications and biology, see Vitamin B12 Health Professional Fact Sheet , which outlines deficiency care and dosing context for clinicians