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2015;45:E5361
Pyroptosis is a novel inflammatory form of programmed cell death defined as gasdermin-mediated programmed necrosis (Shi et al., 2015, 2017)
In the early adhesion phase, immune defenses are active: neutrophils and M1 macrophages target bacteria via phagocytosis, oxidative bursts, increased antimicrobial peptides (AMPs), reactive oxygen species (ROS), and pro-inflammatory cytokines (IL-1, IL-6, TNF-) and chemokines
The risk is lower when combined with metformin alone
It operates as a licensed telehealth platform connecting patients with independent licensed healthcare providers
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