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Always use with caution

This has been demonstrated in multiple studies with rats and swine, where growth hormone levels significantly increased after injections without impacting ACTH and cortisol plasma levels: In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml)

Given that PS on the cell surface may trigger several reactions, this abnormality may contribute to the erythrocyte pathology commonly encountered in chronic uremia, including ionic transport defects, osmotic alterations, deformations, fragility, and coagulation abnormalities

Ipamorelin is not FDA-approved and is used off-label