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Data availability All data generated or analyzed during this study are included in this published article (and its supplementary information files) or are available from the corresponding author on reasonable request
According to a systematic review and meta-analysis published in Cureus , tirzepatide produced significantly greater weight loss than semaglutide across multiple studies, with benefits increasing at higher doses and longer treatment durations
Rimonabant, an early-generation CB1 antagonist, was withdrawn due to central side effects, while new-generation CB1 antagonists with limited bloodbrain barrier penetration are now under development
10.1056/NEJMoa012908 146
Australia's medicines regulator has issued a safety warning over the potential risk of suicidal thoughts and behaviours when taking Ozempic-style drugs
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