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In terms of mechanism, multiple signaling pathways modulate apoptosis
The pore-forming mechanism can be further categorized into two models: barrel-stave pore and toroidal pore (Kumar et al., 2018
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Studies in the model organism Caenorhabditis elegans have demonstrated that different FOXO isoformsparticularly DAF-16Aexert a significant influence on lifespan extension by activating or repressing specific genes such as gst-20 and srr-4, which either promote or inhibit longevity-associated mechanisms
Urea (8 M) was added to the precipitate to dissolve the RIPA-insoluble protein components
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