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Malnutrition was an indication for using the high-risk treatment line when two treatment lines were used to determine need for NAC treatment in the UK [75]
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Targeted analysis was performed using the same chromatographic conditions but with the instrument operating in a parallel reaction monitoring (PRM) method in which targeted HCD MS2 scan were acquired on 12 precursor ions, corresponding to 3 proteins, using an isolation windows of 0.7 m/z (Supplementary Data 1)
The short answer is that each of these works on growth hormone but through different mechanisms, and the clinical use cases do not overlap perfectly
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