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Studies consistently show 10 to 30 percent of metformin users develop low b12 levels over years of use

If reticulocytes have not increased after treatment or if reticulocyte counts do not continue at least twice normal as long as the hematocrit is less than 35%, diagnosis or treatment should be reevaluated

Potential Side Effects of B12 Shots Although it is rare some people can have some mild to more severe side effects from vitaminB12 shots

Vitamin B12 (cyanocobalamin) Normal blood flow, brain functionality, heart and nervous system functions, are all served by the essential vitamin

Vitamin B12 is essential for the production of red blood cells, the maintenance of nerve cell function, and the normal metabolism of fats and carbohydrates