A dedicated phase 2a substudy in people with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) used MRI to measure liver fat and found that, after 24 weeks, retatrutide reduced relative liver-fat content by about 81% at the 8 mg dose and about 82% at 12 mg, versus essentially no change on placebo
Broccoli, leafy greens, and tomatoes also contribute meaningful amounts
While formal guidelines from organizations like ACSM and NSCA often specify intensity ranges based on percentages of one-rep max (e.g., 70-85% 1RM for hypertrophy/strength) 39 , these precise targets can be impractical and intimidating for beginners, especially those navigating potential GLP-1 side effects like fatigue or nausea
The Toronto-based company had paused research and development while pursuing financing
A separate ~10,000-patient cardiovascular outcomes trial (TRIUMPH-Outcomes) won't report until 20282029