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An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

The main objectives were to measure the percentage change in body weight and the proportion of participants who achieved at least a 5% weight loss by week 68

95% CI 1.4, 9.3) on the Mattis Dementia Rating Scale.79 Two major studies were later published by the same UK research group who conducted an analogous randomised placebo-controlled trial, though double blind, in 62 patients with moderate PD on antiparkinsonian treatment and confirmed an effect favouring add-on exenatide (MD 3.5

10.1186/s13287-021-02382-x 127 LiuH.XuX.HanT.YanL.ChengL.QinY.et al (2017)