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Moreover, mitochondria-targeted antioxidant Mito-Tempo alleviates diabetic tubular injury and TECs apoptosis by reducing mitochondrial double-stranded RNA release and inhibiting the activation of the PKR/eIF2 signaling pathway (109), indicating that mitochondria quality control dysfunction is a significant upstreaming point in regulating apoptosis

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Curr Ther Res 1985;38:256-264

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