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The sterol regulatory element-binding protein (SREBP) family of transcription factors plays a crucial role in lipid metabolism by regulating the expression of a series of enzymes required for lipid synthesis, and nuclear fragments of transcriptionally active SREBPs (nSREBPs) are unstable, degraded by the ubiquitin-proteasome pathway

Oxidative stress refers to a state where there is an elevated production of reactive oxygen species (ROS) or reactive nitrogen species (RNS), coupled with a reduced concentration or diminished activity of antioxidants responsible for neutralizing these reactive species