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* Ozempic ( semaglutide ) has a boxed warning for the risk of thyroid cancer
GLP-1 originating from the gut has a very short circulating half-life of only 12 min due to its rapid inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4) and subsequent clearance through the kidneys
on December 22, 2025 for chronic weight management, with trial-reported mean weight loss around 16.6%
This indicates a statistically significant association between treatment group and pregnancy status, with semaglutide use associated with a lower overall pregnancy rate compared to controls
For optimal safety, physicians should assess patients' psychiatric history and mental state before starting treatment
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