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"Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults." Neurology , 78(17), 1346-1353

MIC injections have neither

[10] [23] Vials should be stored at controlled room temperature between 20 C and 25 C, shielded from light and excessive heat, and must never be frozen

This condition is rare but has been reported in several breeds, including: Border Collies Beagles Chinese Shar-Peis Giant Schnauzers Australian Shepherds Treatment of cobalamin deficiency When left untreated, cobalamin deficiency can potentially lead to serious health problems

however, the quality of available supporting evidence was low (269)