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Aug 12022;163(8):1432-1445

For the kidney, degeneration of glomerular structure and dilatation of Bowmans space, degeneration of proximal and distal tubule, vascular congestion and inflammatory cell infiltration were taken into consideration

Mutagenesis 17 , 471481 (2002)

Subeffective dosages of metformin combined with L-NAME and 7-NI reduced CQ-induced scratching behavior, whereas L-arginine reversed the effect, indicating the involvement of the NO pathway in pruritus [14, 15]