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According to the SmPC, no dose adjustment is required for patients with mild to moderate renal or hepatic impairment, as pharmacokinetic changes across these populations are not clinically relevant, but use is not recommended in cases of severe renal or hepatic impairment due to limited experience
What happens to my RxSpan MD plan if compounded GLP-1 rules tighten further
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408 Studies have shown that the loss of GLP-1R in astrocytes can impair mitochondrial integrity, leading to the dysfunction and inhibition of glucose uptake and -oxidation
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