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Pyrroloquinoline quinone, a redox-active o-quinone, stimulates mitochondrial biogenesis by activating the SIRT1/PGC-1 signaling pathway

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The UA/CRE ratio is widely used as a biomarker for evaluating the risks of metabolic syndrome, hypertension, and cardiovascular disease [5, 22, 34]

A similar diabetic model, echocardiographic and hemodynamic studies revealed that alogliptin (12.5 mg/kg/d for 12 weeks) decreased diastolic dysfunction, ventricular hypertrophy and interstitial fibrosis