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As GLP-1Rs are expressed in multiple brain regions, and GLP-1RAs such as liraglutide and lixisenatide can penetrate the blood-brain barrier, liraglutide and exendin-4 can be vagus-dependent or independent in the suppression of the food intake (176)
Liver : Metformin activates AMP-activated protein kinase (AMPK) resulting in suppression of fatty acid synthesis and gluconeogenesis
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2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis
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