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However, the return of appetite, changes in energy levels, shifts in mood, and alterations in digestive function that occur after stopping are sometimes described as "withdrawal-like" even though they are technically just the resolution of the drug effects

In this interim analysis of 72 weeks, data from 800 patients were reported

1 Introduction Obesity is a chronic, progressive metabolic disease associated with major cardiometabolic morbidity and growing global prevalence ( Conventional explanations have largely centred on gastrointestinalcentral homeostatic pathways, emphasising the contributions of enhanced satiety and delayed gastric emptying to reduced intake ( Recent reviews have started to discuss GLP-1RA-related changes in eating behaviour, but most of them mainly focus on outcomes such as body weight, energy intake, craving, or neuropsychiatric adverse events, rather than treating eating experience as a separate issue ( Against this background, this review examines GLP-1RA-associated changes in eating experience as a multilevel biological phenomenon rather than a uniform taste disorder. We use a sensorylikingwanting framework to organise evidence across peripheral taste signalling, brainstem interoceptive integration, and central reward-related pathways

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16 Macrophages and lymphocytes in the ovarian tissue of PCOS patients secrete large amounts of TNF- and IL-6, resulting in inhibition of the formation of dominant follicles and apoptosis of granulosa cells