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In: Feingold KR, Anawalt B, Boyce A, et al, eds

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Metformin is absorbed in the small intestine and excreted unchanged by the kidneys, with a plasma half-life of approximately 46 hours

The 2020 systematic review by Galeano and colleagues across 34 eligible studies confirmed the mechanism: PDRN promotes physiological tissue repair through salvage-pathway nucleotide recycling and A2A receptor activation [32]

Cell Death Dis 13(12):1070 Muller F et al (2023) Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation