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Microdosing offers a potential middle ground, using lower doses to maintain some level of receptor activation, appetite regulation, and metabolic benefit without the full side effect burden of higher doses

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Preclinical studies found that treating neuronal, nematode, or rodent AD models with NR resulted in induction of a mitochondrial stress response, including UPR mt and mitophagy, reduced proteotoxic stress, and decreased A accumulation 243

Mitochondria, known as the cells powerhouses, are deemed crucial for ATP production and maintaining cellular metabolism

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