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Abstract Nutraceuticals represent promising strategies for preventing, delaying and addressing premature aging of the skin, especially as women advance in years (particularly after 30 years of age, when estrogen levels begin to decline, and remarkably after menopause when estrogen production ceases from the ovaries)

Treatment protocols are individualized and monitored under provider supervision to ensure safety, tolerability, and appropriate clinical oversight

Robert Finney, MD, is a board-certified dermatologist and founder of Soho Skin and Hair Restoration in New York City James OSullivan, Ph.D., is a postdoctoral research associate in developmental biology and cell metabolism

Upon successful model establishment, GABA (20mg/kg/day) was administered by gavage to the treatment group, and the TS group received the same volume of normal saline for 4 weeks

Ninhydrin assay (Bates et al