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November 13, 2023
To overcome these limitations, combination strategies are under active exploration
Finally, FGF21 reduces expression and activation of the NLRP3 inflammasome in vascular endothelial cells in diabetic mice (184), which both protects the cells themselves and reduces further inflammatory damage by suppressing pyroptosis and immune cell recruitment (185)
The intention is also to allow the peptide to come directly in contact with the gut lining
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