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While the long-term safety of ipamorelin has yet to be evaluated, we can surmise that, as a growth hormone (GH) secretagogue, long-term ipamorelin therapy may indirectly produce side effects associated with elevated GH levels

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In terms of metabolic parameters, all the treated arms had beneficial changes in their HbA1c%, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels, with the Sema+-MSTN+-ActA arm, which showed the largest combination of fat decrease and lean mass increase, showing the biggest beneficial changes (Fig