Other side effects include vomiting (5% to 9%), diarrhea (8%), stomach pain (6% to 7%), and constipation (3% to 7%)
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Others want evidence of prior diet and exercise efforts
References for the retatrutide data: Jastreboff et al., NEJM 2023: Sanyal et al., Nature Medicine 2024: Giblin et al., TRIUMPH rationale, Diabetes Obesity Metabolism 2025: How to Minimize Side Effects and Maximize Comfort GLP-1s can cause nausea, constipation, and appetite suppression