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Clinical trials have also demonstrated the therapeutic utility of GLP-1RAs in metabolic liver disease, with liraglutide and semaglutide showing improvements in steatohepatitis and fibrosis
Although the mechanisms are not yet fully understood, rodent and human studies show that GIP plays a role in the regulation of lipolysis and lipogenesis in adipose tissue, which could contribute to improved lipid homeostasis and whole body energy metabolism [23, 24]
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If a scheduled dose of semaglutide is missed, it should be taken as soon as possible within five days after the missed dose
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