Eur J Obstet Gynecol Reprod Biol 2014;180:148-52
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Taken together, preclinical and clinical studies have demonstrated that GLP-1 receptor agonists exert pleiotropic effects extending beyond glycemic control, influencing multiple organ systems including the nervous, respiratory, hepatic, renal, cardiovascular, reproductive, and immune systems (Figure 4)
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The subsequent discovery of glucagon-like immunoreactivity in the gut led to the realization that proglucagon is synthesized in enteroendocrine cells intercalated between enterocytes and distributed throughout the intestine