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The overwhelming dominance of ROS generated by enzymes like NADPH oxidases and xanthine oxidase over antioxidants like superoxide dismutase causes cell injury and tissue damage through direct injury, lipid peroxidation and protein oxidation leading to protease release and antioxidant and antiprotease enzyme inactivation as well as alteration of transcription factors activator protein-1 and NFB

TNF-cell surface death receptors, which cause apoptosis, are expressed in renal tubular cells (Feldenberg et al

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Identifying new, secure CRMs will therefore be important