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Patients Inadequately Controlled on Basal Insulin GetGoal-L-Asia randomised 311 patients with long-duration diabetes (mean 13.9 years) who were inadequately controlled on basal insulin to lixisenatide 20 g OD ( n = 154), or placebo ( n = 157) for 24 weeks [14]

Condition of the patient

Mechanisms of Action of GLP-1RAs: Beyond Glycaemic Control Endogenous glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted by intestinal L cells and brainstem neurons in response to nutrient intake

Of note, NMNH has been recently declared self-affirmed GRAS, which should accelerate its clinical development

J Immunol 175 : 69686975, 2005