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Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide

doi: 10.3389/fphar.2025.1610512 Received 12 April 2025 Accepted 15 May 2025 Published 30 May 2025 Volume 16 - 2025 Edited by Karuna Rasineni, University of Nebraska Medical Center, United States Reviewed by Asher Rajkumar Rajan, University of Nebraska Medical Center, United States Akash Batta, Dayanand Medical College & Hospital, India Updates Copyright 2025 Li, Huang, Wang, Huang, Luo and Huang

A small subset of patients (approximately 47% in clinical trials) discontinue semaglutide due to intolerable gastrointestinal side effects that do not adequately resolve

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These physiological effects mean that food takes much longer to pass through our digestive system