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KLOW's mechanism as a Klotho mimetic suggests theoretical risks including phosphate dysregulation, hypoglycemia when combined with other glucose-lowering agents, and potential immunogenicity with repeated subcutaneous dosing
10.1038/s41598-023-49054-9 229 KongpichitchokeT.HsuJ.-L.HuangT.-C
Via the incretin pathway, they stimulate insulin release, suppress glucagon release, slow down gastric emptying, and enhance central satiety signal
136 ZhangJ
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