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Further research is needed to improve our understanding of their effects on obesity-related comorbidities and the underlying mechanism, whether involving direct effects on target tissues or mediated by improvement in BW, glucose levels and other CV risk factors

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The gene has been annotated in the human genome on the chromosome X, it is composed of 13 exons encoding only one splice variant, and has been cloned in 1999 (Sloan and Mager, 1999)

Many patients with type 2 diabetes notice better blood glucose control within the first 12 weeks of starting treatment, even at initial lower doses