tirzepatide surmount-1 nejm 2022 weight loss percent 📊 Semaglutide 2.4mg: −13.7% (SURMOUNT-5 head-to-head), 📊 15mg: −20.2% weight loss (same trial, 2025), 📊 Retatrutide 12mg: −28.7% weight loss (TRIUMPH-4, Phase 3, Dec Tirzepatide for Obesity: Highlights from

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While semaglutide offers significant benefits for individuals with type 2 diabetes and obesity, awareness of the potential signs and symptoms of gallbladder issues is critical

We also hypothesize that GLP-1 axons that are apposed to GLP-1R-negative SPNs may regulate these cells directly via synaptic glutamate release 58,59 , and indirectly by GLP-1 release that might modulate the activity of nearby GLP-1R + terminals on the surface of SPNs 60

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