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Semaglutide for managing overweight and obesity Chapter 1: Recommendations (TA875)

Finally, there are some warnings associated with the use of semaglutide or tirzepatide: those who have a history of pancreatitis should not use either medication

Semaglutide is generally avoided during pregnancy, and pregnancy planning should include a medication review well before conception

Every 5 kg of weight loss independently reduces systolic blood pressure by approximately 3 to 5 mmHg, reduces triglycerides, improves HDL cholesterol, reduces insulin resistance, decreases systemic inflammation, and reduces mechanical strain on the heart

Activation of these cells stimulates the secretion of somatostatin, a potent inhibitor that acts locally on neighboring -cells to suppress glucagon release (Zheng et al., 2024)