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SOURCE: Zevay Source: Zevay
The bidirectional communication between the gut microbiome and the central nervous system (CNS) is known as the gut-brain axis, which includes two key barriers, namely blood-brain barrier (BBB) and the gut barrier, and has become a crucial framework for understanding the pathophysiological mechanisms of various neurological disorders
[13] One Dutch study found that after adjustment for gender and age, there was a statistically significant negative association between the use of metformin and vitamin D status, with those who did not use a vitamin D supplement having levels of vitamin D 14.4 percent lower than controls
Users who expected rapid changes in weight or appetite were often disappointed
Additionally, rapid weight loss itself is associated with adaptive thermogenesis , a physiological response where the body conserves energy by reducing heat production
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