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Retatrutide is a once-weekly injection that mimics three hormones involved in appetite, blood sugar, and how the body uses energy: GLP-1: lowers appetite and blood sugar GIP: lowers appetite and blood sugar Glucagon: increases energy expenditure and the breakdown of stored fat, including fat in the liver The glucagon component is what separates retatrutide from semaglutide, which mimics one hormone (GLP-1), and tirzepatide, which mimics two (GLP-1 and GIP)

Dulaglutide reduced MACE by 12% in REWIND

This is called the first-pass effect, and it can reduce the effectiveness of some medications

A licensed clinician should supervise all peptide use to ensure the product comes from reputable compounding pharmacies and meets necessary safety standards

is a co-founder of BreStem Therapeutics