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Nonetheless, different animal models deficient for GLP-1 signaling, in addition to human studies, prove the dispensability of GLP-1 for surgical success ( On the other hand, PYY has been proven to be upregulated, and necessary, for RYGB mediated restoration of the diabetic islets, and overall cure of diabetes in rats (154)

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While some observational data suggest metformin may have renoprotective properties through AMPK activation, no randomized trial has demonstrated a renal composite endpoint benefit 3

This may in part be due to a positive perception of the relative ease of weight loss with the medication