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Pathophysiology of Type 2 DM All forms of diabetes, including type 1, type 2, and gestational diabetes, share one defining feature: hyperglycemia, or chronically elevated blood glucose levels

1b-e, 5c, 8a are provided as a Source Data file

Given that glutathione is a tripeptide composed of glutamate, glycine, and cysteine, glutamine-derived glutamate and cysteine need to be ligated by glutamate-cysteine ligase (GCL), which itself comprises two separately encoded proteins: a catalytic subunit (GCLC) and a modifier subunit (GCLM) 53,54

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The unexpected paradoxical worsening of psoriatic lesions after treatment with liraglutide was hypothesized to be due to cytokine imbalance with the release of IFN- and leukocyte chemotaxis after liraglutide-induced inhibition of TNF-, IL17, and IL23